质量控制：95%+
纯度级别：分析纯AR贮存方法：避光储存GalNAc-CPG允许合成siRNA-GalNAc缀合物。N-乙酰半乳糖胺（GalNAc）是一种定义明确的肝脏靶向部分，得益于其与去唾液酸糖蛋白受体（ASGPR）的高亲和力。GalNAc CPG allows the synthesis of siRNA - GalNAc laced. N-acetyl galactosamine (GalNAc) is a well-defined liver targeting part, due to its to sialic acid glycoprotein receptor (ASGPR) with high affinity.通过将其直接与寡核苷酸结合或将其修饰到特定的递送系统作为靶向部分，GalNAc在核酸疗法的发展中取得了引人注目的成功。Directly by the combined with few nuclear wast, acid or the targeted delivery system as part of the modification to the specific, GalNAc in the development of nucleic acid therapy has achieved remarkable success.N-乙酰化的半乳糖胺（GalNAc）偶联修饰是当前最常用的小核酸药物递送系统。GalNAc是去唾液酸糖蛋白受体（ASGPR）配体，能以nM级高亲和性结合ASGPR，随后受体在网格蛋白介导的内吞作用下将GalNAc及核酸摄取进入细胞。GalNAc偶联修饰的优势在于偶联的核酸分子量较小，并且作用时效长达数月。但由于ASGPR仅在肝实质细胞特异性高表达，存在组织局限性。N - b of cool galactosamine (GalNAc) coupling modification is the most commonly used small nucleic acid drug delivery system. GalNAc is to sialic acid glycoprotein receptor (ASGPR) ligands, nM level high affinity to ASGPR, then under the action of receptor in clathrin mediated endocytosis GalNAc and nucleic acid uptake into the cells. GalNAc coupling modified advantage lies in the coupling of the nucleic acid molecular weight is small, and the effect of aging for months. But as a result of ASGPR only high specificity in the liver parenchyma cells, limitations exist organization.
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